p-Toluenesulfonic acid monohydrate → HCID 22241594, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-[3-(2-methoxy-ethoxymethoxy)-benzyloxymethyl]-pyridine (171 mg, 0.56 mmol, example 73) in CH3OH (1.9 mL) is added p-toluenesulfonic acid monohydrate (148 mg, 0.78 mmol). The mixture is heated to 60° C. and stirred for 1.5 hrs, then cooled to room temperature and diluted with EtOAc. The organic layer is washed with sat NaHCO3, brine, then dried over MgSO4 and concentrated to give the title compound as a white crystalline solid. MS (ESI) 216 (M+H)+.

Provenance & Evidence