Boron tribromide → HCID 22241506, compound

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Reaction Steps

Boron tribromide (1.3 mL, 1.0 M in dichloromethane, 1.3 mmol) is added to a solution of isobutyl 2-[3-(methoxy)-phenylsulfanylmethyl]-6-methyl-benzoate (194 mg, 0.56 mmol, example 82) in dichloromethane (3 mL) at 0° C. and then the reaction is stirred at room temperature 3 h. The reaction is then partitioned between sodium bicarbonate solution and ethyl acetate. The organic phase is dried over magnesium sulfate, concentrated and purified by column chromatography (silica, 15% ethyl acetate in hexanes) to provide the title compound. MS (EI) 330 (M)+.

Provenance & Evidence