Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Iodophenol | HCID 12272 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(Chloromethoxy)-2-methoxyethane | HCID 77590 | — |
| Reactant | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22241268 | HCID 22241268 | — |
Reaction Steps
To a suspension of 60% sodium hydride (1.76 g, 44 mmol) in THF (10 mL), cooled to 0° C., is added 3-iodophenol (8.8 g, 40 mmol) and methoxyethoxymethyl chloride (5 mL, 44 mmol) in THF (50 mL). Then DMPU (10 mL) is added, the cooling bath is removed and the reaction is stirred for an hour. The reaction is diluted with ether, washed with water and brine and the organic layer dried over magnesium sulfate. The solvent is removed in vacuo to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07005440B1 |
|---|
| Source dataset | uspto-grants-2006_02 |
|---|
| ORD ID | ord-c5a19ed4513c4d0b80ce3ee5bab17d79 |
|---|
| Source note | uspto-grants-2006_02 |
|---|
