2-Nitrobenzoyl chloride → HCID 3352368, compound

HRID 892275Notes

Reaction equation

HRID 892275 reaction equation
[N+](C1C=CC=C[C:5]=1[C:6](Cl)=[O:7])([O-])=O.[C:13]([NH:17][C:18](=[O:28])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N+:25]([O-])=O)([CH3:16])([CH3:15])[CH3:14]>>[C:13]([NH:17][C:18](=[O:28])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[NH:25][C:6](=[O:7])[CH3:5])([CH3:16])([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 118752-Nitrobenzoyl chlorideHCID 710774N-(tert-butyl)-2-nitrobenzamide

Product 1

HCID 3352368HCID 3352368, compound

Procedure

The method of Example 3 is repeated using 2-nitrobenzoyl chloride in the amidation step. This yields N-tert-butyl-2-nitrobenzamide (CPI1035).

Sources & evidence

ORD record
ord-66df1ee9bfef427abd65cb5416917fea
Source dataset
uspto-grants-2006_02
Patent number
US07005546B2

Reaction notes

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