4-Nitrobenzenesulfonamide → HCID 10211643, compound

HRID 892287Notes

Reaction equation

HRID 892287 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:20])[C:10]=1[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Br:19])[CH:14]=1)[C:5]([OH:7])=O.[N+:21]([C:24]1[CH:29]=[CH:28][C:27]([S:30]([NH2:33])(=[O:32])=[O:31])=[CH:26][CH:25]=1)([O-:23])=[O:22]>>[Br:20][C:9]1[CH:8]=[C:4]([CH:3]=[C:2]([Br:1])[C:10]=1[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Br:19])[CH:14]=1)[C:5]([NH:33][S:30]([C:27]1[CH:26]=[CH:25][C:24]([N+:21]([O-:23])=[O:22])=[CH:29][CH:28]=1)(=[O:32])=[O:31])=[O:7]

Participants

3

Reactant 2

HCID 227844-NitrobenzenesulfonamideHCID 22242280HCID 22242280, compound

Product 1

HCID 10211643HCID 10211643, compoundYield 69%

Procedure

3,5-Dibromo-4-(3-bromobenzyloxy)benzoic acid (0.13 mmol) was coupled with 4-nitrobenzenesulphonamide (0.64 mmol) using the procedure described in Example 31. Purification on column (silica gel, chloroform/methanol 9:1) gave 58 mg (69%) of N-[3,5-dibromo-4-(3-bromobenzyloxy)benzoyl]-4-nitrobenzene-sulphonamide.

Workup

  1. customPurification on column (silica gel, chloroform/methanol 9:1)

Sources & evidence

ORD record
ord-dfee01b673e54a9c8af4f0ab29df98fd
Source dataset
uspto-grants-2006_02
Patent number
US07005538B1

Reaction notes

Loading…