Acetic Anhydride → HCID 10166850, compound

HRID 892328Notes

Reaction equation

[O:1]=[C:2]1[C:7]2[N:8]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[S:21]([NH2:24])(=[O:23])=[O:22])[N:9]=[C:10]([C:11]([F:14])([F:13])[F:12])[C:6]=2[CH2:5][CH2:4][N:3]1[C:25]1[CH:30]=[CH:29][C:28]([N:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]2=[O:37])=[CH:27][CH:26]=1.[C:38](OC(=O)C)(=[O:40])[CH3:39]>>[C:38]([NH:24][S:21]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[N:8]1[C:7]2[C:2](=[O:1])[N:3]([C:25]3[CH:30]=[CH:29][C:28]([N:31]4[CH:36]=[CH:35][CH:34]=[CH:33][C:32]4=[O:37])=[CH:27][CH:26]=3)[CH2:4][CH2:5][C:6]=2[C:10]([C:11]([F:12])([F:14])[F:13])=[N:9]1)(=[O:22])=[O:23])(=[O:40])[CH3:39]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 10186702HCID 10186702, compound

Product 1

HCID 10166850HCID 10166850, compound

Procedure

The sulfonamide of Example 121 was acetylated with acetic anhydride to afford the title compound. MS (ES+): 572.1 (M+H).

Sources & evidence

ORD record: ord-3a3b29057e6641a28c9a01aef1132555
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07005435B2

Reaction notes

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