HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 892333Generated: October 30, 2026
Methanol → 5-(2-Amino-1,3-benzothiazol-6-yl)imidazolidine-2,4-dione
https://huagongshe.com/reaction/892333
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | Ammonium Carbonate | HCID 517111 | — |
| Reactant | 2-Aminobenzo[d]thiazole-6-carbaldehyde | HCID 13821541 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-(2-Amino-1,3-benzothiazol-6-yl)imidazolidine-2,4-dione | HCID 13821542 | — |
Reaction Steps
22.5 g (0.126 mol) of 1b, dissolved in 400 ml of methanol, are added dropwise to a solution of 50.9 g (0.531 mol) of ammonium carbonate and 9.6 g (0.196 mol) of sodium cyanide in 400 ml of water, and the mixture is stirred at 60° C. for 20 hours. After the methanol has been removed by distillation in vacuo, the remaining solution is acidified, at 0° C., to pH 2 with 2N HCl, then the pH is returned to 4 with 2N sodium hydroxide solution, and the precipitated product is filtered off with suction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | USRE033948 |
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| Source dataset | uspto-grants-1992_06 |
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| ORD ID | ord-3da1ff122f6c4e92a7c09a8bc6f98508 |
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| Source note | uspto-grants-1992_06 |
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