Methyl [[(methoxycarbonyl)amino](methylthio)methylene]carbamate → methyl 2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylate

Participants

Reaction Steps

20 g (0.12 mol) of methyl 3,4-diaminobenzoate and 24.8 g (0.12 mol) of N,N'-dicarbomethoxy-S-methylisothiourea in 180 ml of DMF are heated under reflux for 4 hours. The DMF is then removed by distillation, the residue is vigorously stirred with water, and the crystals which have separated out are filtered off with suction and washed with water. After drying of the substance at 40° C. in vacuo, the product is suspended in acetone and then filtered off with suction.

Provenance & Evidence