HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisobutylaluminum hydride → 1,3-Dihydro-5-(hydroxymethyl)-2H-benzimidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisobutylaluminum hydride | HCID 14487 | — |
| Reactant | methyl 2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylate | HCID 10352553 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1,3-Dihydro-5-(hydroxymethyl)-2H-benzimidazol-2-one | HCID 14518358 | — |
Reaction Steps
24.6 g (0.128 mol) of 20a are suspended in THF and stirred with 624.8 ml (0.768 mol) of DIBAL (20% strength solution in toluene) at -70° C. overnight in analogy to Example 1a.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE033948 |
| Source dataset | uspto-grants-1992_06 |
| ORD ID | ord-4fd945ec6cfa414a82b6540699ada811 |
| Source note | uspto-grants-1992_06 |