Nitric Acid → HCID 19894998, compound

HRID 892354Notes

Reaction equation

HRID 892354 reaction equation
[C:1]([N:4]1[C:9]2[CH:10]=[CH:11][C:12]([NH:14][C:15](=[O:17])[CH3:16])=[CH:13][C:8]=2[O:7][CH2:6][CH2:5]1)(=[O:3])[CH3:2].[N+:18]([O-])([OH:20])=[O:19]>C(OC(=O)C)(=O)C>[C:1]([N:4]1[C:9]2[CH:10]=[C:11]([N+:18]([O-:20])=[O:19])[C:12]([NH:14][C:15](=[O:17])[CH3:16])=[CH:13][C:8]=2[O:7][CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 19992625HCID 19992625, compound

Product 1

HCID 19894998HCID 19894998, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

To a stirred solution of 5 (5.0 g) in acetic anhydrid (50 ml) in an ice bath was added slowly fuming nitric acid (5 ml). The mixture was stirred for 0.5 h and the yellow precipitate was filtered, washed with water three times and dried under reduced pressure to give 4.9 g (82%) of 6: mp 199°-202° C.; MS m/e 279 (M+).

Workup

  1. filtrationthe yellow precipitate was filtered
  2. washwashed with water three times
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-f74d1b0940244d10a53786646b7ed884
Source dataset
uspto-grants-1992_06
Patent number
US05118323

Reaction notes

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