Dicyclohexylcarbodiimide → HCID 54135793, compound

Participants

Reaction Conditions

Reaction Steps

In a 50 ml round flask were charged 86.3 mg (0.39 mmol) of (R)-4-hydroxybenzoic acid 1-(methoxycarbonyl)ethyl ester obtained in Example 1-2), 134.6 mg (0.35 mmol) of 2-(4-dodecyloxyphenyl)-5-pyrazinecarboxylic acid, 4.3 mg (0.035 mmol) of N,N-dimethyl-4-aminopyridine, and 5 ml of methylene chloride, followed by stirring at 25° C. To the mixture was added 79.4 mg (0.39 mmol) of DCC to conduct a reaction at 25° C. for 18 hours. After completion of the reaction, the reaction mixture was worked-up in the same manner as in Example 1-3) to obtain 27.6 mg (0.047 mmol) of Compound (11) in a yield of 13% based on 2-(4-dodecyloxyphenyl)-5-pyrazinecarboxylic acid.

Provenance & Evidence