Water → HCID 19895299, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of HNa (50%, 1.06 gr) in 40 ml of dry THF, stirred at 0° C., a solution of 5.12 gr of 4 in 40 ml THF was added dropwise. After 30 min, CH3I (6.6 ml) was added and the mixture was stirred at 0° C. for 6 hours, then overnight at room temperature. Water was added and the mixture was extracted with diethyl-ether, the organic layer was washed with water until neutral, then with brine, dried and evaporated. The residue was purified on alumina column (eluent CH2Cl2) to yield 4.8 gr of 5 (86%).

Provenance & Evidence