Acetic Anhydride → HCID 578922, compound

HRID 892417Notes

Reaction equation

HRID 892417 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>>[C:10]([O:9][C:4]1[CH:5]=[C:6]([CH3:8])[CH:7]=[C:2]([CH3:1])[CH:3]=1)(=[O:12])[CH3:11]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 79483,5-Dimethylphenol

Product 1

HCID 578922HCID 578922, compoundYield 103.1%

Procedure

206.5 g (1.69 mol) of 3,5-dimethylphenol and 337.3 g (3.30 mol) of acetic anhydride were refluxed for 1 h and then stirred at RT overnight. The mixture was poured onto water and extracted with methylene chloride. The organic phase was washed with sodium hydroxide solution and water, dried and concentrated under reduced pres-sure. 286 g of 3,5-dimethylphenyl acetate were obtained.

Workup

  1. additionThe mixture was poured onto water
  2. extractionextracted with methylene chloride
  3. washThe organic phase was washed with sodium hydroxide solution and water
  4. customdried
  5. concentrationconcentrated under reduced pres-sure

Sources & evidence

ORD record
ord-a5468a53ca4044608cfedb822269f63a
Source dataset
uspto-grants-1992_06
Patent number
US05118682

Reaction notes

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