反应详情

A stirred solution of 6-amino-2-(2-propoxyphenyl)-pyrimidin-4[3H]-one (0.5 g) and acetic anhydride was heated under reflux for 2.5 hours. The cooled reaction mixture was evaporated under reduced pressure to yield a residue which was washed with water and recrystallised twice from methanol to yield the title compound, 0.29 g, m.p. 230°-1° C.

1. temperatureunder reflux for 2.5 hours
2. customThe cooled reaction mixture
3. customwas evaporated under reduced pressure
4. customto yield a residue which
5. washwas washed with water
6. customrecrystallised twice from methanol