Hydrochloric Acid → HCID 178458310, compound

Participants

Reaction Steps

A stirred mixture of diethyl malonate (17.62 g), 2-propoxybenzamidine methanesulphonate (29.03 g) and sodium ethoxide in ethanol (from sodium, 6.9 g, and ethanol, 150 ml) was heated under reflux for 6 hours. The cooled reaction mixture was evaporated under reduced pressure to yield a residue which was dissolved in water. Concentrated hydrochloric acid was added to the aqueous solution to yield the title compound, 21.56 g. A sample (0.5 g) of this material was recrystallised twice from methanol to yield the pure title compound, 0.119 g, m.p. 224°-5° C.

Provenance & Evidence