1-Butanol → HCID 178458304, compound

Participants

Reaction Steps

A stirred solution of 4,6-dichloro-2-(2-propoxyphenyl)pyrimidine (16.68 g) in concentrated hydrochloric acid (40 ml), n-butanol (80 ml) and water (40 ml) was heated under reflux for 3 hours. The cooled reaction mixture was evaporated under reduced pressure to yield a residue which was washed with water and diethyl ether and recrystallised from isopropanol to yield the title compound, 8.46 g, m.p. 115.5°-11 6.5° C. A sample (1 g) of this material was recrystallised twice from isopropanol to yield the pure title compound, 0.42 g, m.p. 118°-118.5° C.

Provenance & Evidence