Tetrahydrofuran → HCID 13583743, compound

Participants

Reaction Steps

To a 0° C. solution of ethyl N-benzylglycinate (8 g) in tetrahydrofuran (4 ml) and diethyl ether (42 ml) was added simultaneously a solution of K2CO3 (5.72 g) in 20 ml of water and ethyl malonylchloride (6.54 g) in 20 ml diethyl ether. Following the addition the mixture was stirred at 0° for 1 hour then warmed to ambient temperature with stirring for 2 hours. The layers were separated with the organic phase washed once with brine. After drying (Na2SO4) and concentrating, there was obtained 12.5 g (98.8%) of the product as a viscous oil.

Provenance & Evidence