Lithium borohydride → HCID 53921892, compound

Participants

Reaction Steps

N-[(2-Oxo-1-pyrrolidinyl)acetyl]-L-prolyl-L-proline methyl ester (Compound 1) (2.56 g) as obtained in Example 1 was dissolved in a mixture of THF (30 ml) and ethanol (6 ml), to which was added a THF solution of 2 M lithium borohydride (7.3 ml) under ice-cooling. After 3 hours' stirring at room temperature, a 50% acetic acid-methanol solution was added to adjust the pH of the mixture to 6. The residue obtained by concentration was purified by silica gel column chromatography (chloroform-methanol) to give 2.02 g of N-[(2-oxo-1-pyrrolidinyl)acetyl]-L-prolyl-L-prolinol.

Provenance & Evidence