Triethylamine → HCID 54542799, compound

Participants

Reaction Steps

To a solution of N-[(2-oxo-1-pyrrolidinyl)acetyl]-L-prolyl-L-prolinol (965 mg) in DMSO (5 ml) were added triethylamine (2.5 ml) and sulfur trioxide pyridine complex (1.89 g) under ice-cooling, and the mixture was stirred at a temperature of 10°-15° C. for 1 hour. The reaction mixture was concentrated at room temperature, and the residue was purified by silica gel column chromatography (chloroform-methanol) to give 663 mg of N-[(2-oxo-1-pyrrolidinyl)acetyl]-L-prolyl-L-prolinal.

Provenance & Evidence