N-{4-oxo-4-[3-(2-oxo-1-pyrrolidinyl)propylamino]butanoyl}-L-prolinol → N-{4-oxo-4-[3-(2-oxo-1-pyrrolidinyl)propylamino]butanoyl}-L-prolinal

Participants

Reaction Steps

N-{4-Oxo-4-[3-(2-oxo-1-pyrrolidinyl)propylamino]butanoyl}-L-prolinol (85 mg) was dissolved in a mixed solvent of benzene (0.18 ml), DMSO (0.5 ml) and triethylamine (0.18 ml), and sulfur trioxide pyridine complex (200 mg) was added thereto under ice-cooling. After 1 hour's stirring at a temperature of 10°-15° C., the reaction mixture was treated in the same manner as in Example 10-C) to give 55 mg of N-{4-oxo-4-[3-(2-oxo-1-pyrrolidinyl)propylamino]butanoyl}-L-prolinal.

Provenance & Evidence