Sodium Hydroxide → HCID 101990412, compound

HRID 892711Notes

Reaction equation

HRID 892711 reaction equation
[CH3:1][C@H:2]1[O:7][C@@H:6]([O:8][C@H:9]2[C:18]3[C:13](=[C:14]([OH:28])[C:15]([C:20]([NH:22][C@@H:23]([C:25]([OH:27])=[O:26])[CH3:24])=[O:21])=[C:16]([CH3:19])[CH:17]=3)[C:12]3[C:29]([OH:46])=[C:30]4[C:41](=[O:42])[C:40]5[C:35](=[C:36]([OH:45])[CH:37]=[C:38]([O:43][CH3:44])[CH:39]=5)[C:33](=[O:34])[C:31]4=[CH:32][C:11]=3[C@@H:10]2[OH:47])[C@H:5]([OH:48])[C@@H:4]([O:49][C@@H:50]2[O:55][CH2:54][C@@H:53]([OH:56])[C@H:52]([OH:57])[C@H:51]2[OH:58])[C@H:3]1[OH:59].[OH-].[Na+:61]>O.CO>[CH3:1][C@H:2]1[O:7][C@@H:6]([O:8][C@H:9]2[C:18]3[C:13](=[C:14]([OH:28])[C:15]([C:20]([NH:22][C@@H:23]([C:25]([OH:27])=[O:26])[CH3:24])=[O:21])=[C:16]([CH3:19])[CH:17]=3)[C:12]3[C:29]([OH:46])=[C:30]4[C:41](=[O:42])[C:40]5[C:35](=[C:36]([O-:45])[CH:37]=[C:38]([O:43][CH3:44])[CH:39]=5)[C:33](=[O:34])[C:31]4=[CH:32][C:11]=3[C@@H:10]2[OH:47])[C@H:5]([OH:48])[C@@H:4]([O:49][C@@H:50]2[O:55][CH2:54][C@@H:53]([OH:56])[C@H:52]([OH:57])[C@H:51]2[OH:58])[C@H:3]1[OH:59].[Na+:61]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 5464367Benanomicin A

Product 1

HCID 101990412HCID 101990412, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of benanomicin A (82.7 mg) in a mixture of 10 ml of water and 1.1 ml of 0.1M NaOH was lyophilized. The residue was dissolved in 3 ml of methanol and chromatographed on a Sephadex LH-20 column (300 ml) developed with methanol to obtain benanomicin A sodium salt (75.8 mg).

Workup

  1. customchromatographed on a Sephadex LH-20 column (300 ml)

Sources & evidence

ORD record
ord-940d6e7495b64eb5bd277b9f75a40ceb
Source dataset
uspto-grants-1992_06
Patent number
US05120717

Reaction notes

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