(Diethylamino)sulfur trifluoride → HCID 86745886, compound

Participants

Reaction Steps

To (±)-cis-3-Ethyl-4-hydroxymethyl-N-toluenesulfonyl-2-azetidinone (3.9 mg) in CH2Cl2 (0.5 ml) was added diethylaminosulfur trifluoride (DAST) (15μl). The mixture was stirred overnight under nitrogen. The mixture was purified by preparative TLC on a silica gel plate (1000μ) and developed with CH2Cl2 to give the titled compound. NMR(CDCl3): δ1.06(3H, t), 1.6-2.0(2H, m), 2.45(3H, s), 3.26(1H, dt), 4.27(1H, dm), 4.65(1H, m), 4.88(1H, m), 7.37(2H, d), 7.88(2H, d)

Provenance & Evidence