3111-52-2 → HCID 86745887, compound

HRID 892720Notes

Reaction equation

HRID 892720 reaction equation
[CH2:1]([C@H:3]1[C@@H:6]([CH2:7][CH2:8][O:9]S(C2C(C)=CC=CC=2)(=O)=O)[NH:5][C:4]1=[O:20])[CH3:2].[C:21]1([SH:27])[CH:26]=[CH:25][CH:24]=CC=1.[K]>C(O)C>[CH2:1]([C@H:3]1[C@@H:6]([CH2:7][CH2:8][O:9][C:24]2[S:27][CH:21]=[CH:26][CH:25]=2)[NH:5][C:4]1=[O:20])[CH3:2]

Participants

4

Reactant 2

HCID 686835543111-52-2HCID 86745888HCID 86745888, compound

Product 1

HCID 86745887HCID 86745887, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 8 mg of the titled product of Example 10 Step C in 1 ml of absolute ethanol was added a small amount of potassium thiophenol. The resulting mixture was refluxed for 1/2 hour and the product purified by preparative TLC (30% EtOAc in hexane). 1H NMR (CDCl3): δ1.04(3H, t), 1.46-1.98(4H, m), 2.97(2H, t), 3.06-3.16(1H, m), 3.77-3.85(1H, m), 5.99 (1H, broad), 7.16-7.36(5H, m).

Workup

  1. temperatureThe resulting mixture was refluxed for 1/2 hour
  2. customthe product purified by preparative TLC (30% EtOAc in hexane)

Sources & evidence

ORD record
ord-b219d622363a4c52a55c59d39b701a46
Source dataset
uspto-grants-1992_06
Patent number
US05120729

Reaction notes

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