2-Pyrrolidone → HCID 14441092, compound

Participants

Reaction Steps

A mixture of 17.1 g (201 mmol) of 2-oxopyrrolidine and 20 g (167 mmol) of chloropropyl isocyanate was heated with stirring at 95°-105° C. overnight. After cooling, the reaction resolution was refined by silica gel chromatography. The resulting product obtained from the eluate with toluene-ethyl acetate (20/1-10/1 v/v) was washed with ether-n-hexane and then collected by filtration, whereby 27.87 g of the objective compound 1-(3-chloropropylcarbamoyl)-2-oxopyrrolidine (III-2) melting at 57.0°-58.0° C. was obtained as crystals. Yield: 81.0%.

Provenance & Evidence