Bromine → HCID 15005405, compound

HRID 892783Notes

Reaction equation

HRID 892783 reaction equation
[Br:1]Br.[O:3]=[C:4]([CH3:14])[CH2:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1>ClCCl>[Br:1][CH:5]([C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1)[C:4](=[O:3])[CH3:14]

Participants

4

Reactant 2

HCID 24408BromineHCID 15125134-(2-oxopropyl)benzonitrile

Product 1

HCID 15005405HCID 15005405, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Bromine (5.28 g) in dichloromethane (80 ml) was added dropwise at 25° C. over 1 hour to 4-(2-oxopropyl)benzonitrile in dichloromethane (85 ml). The reaction mixture was stirred for 1/2 hour after the addition was complete. The mixture was washed with brine (50 ml), dried over magnesium sulphate and the solvent removed under reduced pressure to yield the title compound as a pale red oil (7.55 g, 96%).

Workup

  1. additionafter the addition
  2. washThe mixture was washed with brine (50 ml)
  3. dry with materialdried over magnesium sulphate
  4. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-ee3ef274294740f08d1c883d4715c28d
Source dataset
uspto-grants-1992_06
Patent number
US05120747

Reaction notes

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