Diethyl Ether → (3-Aminophenyl)(3,4,5-trimethoxyphenyl)methanone

Participants

Reaction Steps

N-tert-butylcarbonyl-3-(3,4,5-trimethoxybenzoyl)aniline (7.10 g, 18.92 mmol), prepared as described above, was dissolved in acetic acid (125 mL, 1.4N) at room temperature. A solution of hydrochloric acid/acetic acid (20 mL) was added and the mixture allowed to stand for 45 minutes. Diethylether (800 mL) was added and the resulting precipitate filtered and dried to yield 3-(3,4,5-trimethoxybenzoyl)aniline (5.24 g, 85.7%) as a tan solid.

Provenance & Evidence