Dimethyl Sulfate → HCID 19894101, compound

Participants

Reaction Conditions

Reaction Steps

N-tert-butoxycarbonyl-3-aminobenzophenone (2 g, 6.7 mmol) in DMF (15 mL) was added to a suspension of sodium hydride (0.54 g, 13.5 mmol) in DMF (70 mL) and the mixture was stirred at 0° C. for 40 minutes. Dimethylsulfate (1.3 mL, 13.5 mmol) was added and the mixture stirred at room temperature for 15 hours. The mixture was partitioned between ethyl acetate and saturated NaCl. The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo to afford the desired material as an orange oil.

Provenance & Evidence