Thiazolidinedione → 5-[4-(2-(4-Chlorophenyl)ethylthio)phenylmethylene]thiazolidine-2,4-dione

HRID 892818Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10][C:11]2[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[S:19]1[CH2:23][C:22](=[O:24])[NH:21][C:20]1=[O:25]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10][C:11]2[CH:18]=[CH:17][C:14]([CH:15]=[C:23]3[S:19][C:20](=[O:25])[NH:21][C:22]3=[O:24])=[CH:13][CH:12]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 5437Thiazolidinedione

HCID 144599684-[2-(4-Chlorophenyl)ethylthio]benzaldehyde

Product 1

HCID 539456615-[4-(2-(4-Chlorophenyl)ethylthio)phenylmethylene]thiazolidine-2,4-dione

Procedure

4-[2-(4-Chlorophenyl)ethylthio]benzaldehyde and thiazolidine-2,4-dione were coupled according to the method of Example 5 to form present title product in similar yield; m.p. 215°-225° C.

Sources & evidence

ORD record: ord-661253dd05c445c6b725f7d6f1d0c0c8
Source dataset: uspto-grants-1992_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05120754

Reaction notes

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