Triethylamine → HCID 10042628, compound

Participants

Reaction Conditions

Reaction Steps

2-Hydroxymethyl-7-phenoxy-1,4-benzodioxane (1.42 g, 5.50 mmol) and triethylamine (1.11 g, 11.0 mmol) are dissolved in methylene chloride (50 mL) and treated with methanesulfonyl chloride (0.94 g, 8.26 mmol) at 0° C. The mixture is stirred at 0° C. for 30 minutes, and diluted with ether. This is washed with aqueous sodium bicarbonate, aqueous 1N hydrochloric acid and saturated aqueous ammonium chloride, dried over magnesium sulfate and evaporated to give 2-methanesulfonyloxymethyl-7-phenoxy-1,4-benzodioxane. The crude oil is used without further purification.

Provenance & Evidence