2-Aminophenol → N-(2-Hydroxyphenyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide

HRID 892883Notes

Reaction equation

[CH3:1][C:2]1([CH3:18])[O:7][CH:6]([C:8]([NH:10][CH2:11][CH2:12][C:13]([OH:15])=O)=[O:9])[C:5]([CH3:17])([CH3:16])[CH2:4][O:3]1.[NH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[OH:26]>>[OH:26][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[NH:19][C:13](=[O:15])[CH2:12][CH2:11][NH:10][C:8]([CH:6]1[C:5]([CH3:17])([CH3:16])[CH2:4][O:3][C:2]([CH3:1])([CH3:18])[O:7]1)=[O:9]

Participants

Reactant 2

HCID 58012-Aminophenol

HCID 189385173-[N-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid

Product 1

HCID 19893786N-(2-Hydroxyphenyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamideYield 98%

Procedure

3-[N-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid (0.26 g) and 0.13 g of o-aminophenol were reacted in the same manner as in Reference Example 15 to obtain 0.34 g of the objective compound (yield: 98%).

Sources & evidence

ORD record: ord-916e5fea93af4a17958f612c9a269dd6
Source dataset: uspto-grants-1992_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05120738

Reaction notes

Loading…