Benzyl (2R)-2-(aminomethyl)pyrrolidine-1-carboxylate → HCID 67795524, compound

HRID 892888Notes

Reaction equation

HRID 892888 reaction equation
[NH2:1][CH2:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9].[CH3:18][C:19]1([CH3:35])[O:24][CH:23]([C:25]([NH:27][CH2:28][CH2:29][C:30](O)=[O:31])=[O:26])[C:22]([CH3:34])([CH3:33])[CH2:21][O:20]1>>[CH2:11]([O:10][C:8]([N:4]1[CH2:5][CH2:6][CH2:7][C@@H:3]1[CH2:2][NH:1][C:30](=[O:31])[CH2:29][CH2:28][NH:27][C:25]([CH:23]1[C:22]([CH3:33])([CH3:34])[CH2:21][O:20][C:19]([CH3:35])([CH3:18])[O:24]1)=[O:26])=[O:9])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 7145101Benzyl (2R)-2-(aminomethyl)pyrrolidine-1-carboxylateHCID 189385173-[N-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid

Product 1

HCID 67795524HCID 67795524, compoundYield 72.3%

Procedure

(R)-2-Aminomethyl-1-benzyloxycarbonylpyrrolidine (750 mg) and 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid (829 mg) were Example reacted in the same manner as in Reference Example 25 to obtain 1.10 g of the ojective compound (yield: 72%).

Workup

  1. customreacted in the same manner as in Reference Example 25

Sources & evidence

ORD record
ord-d734757f8daf4079b21ba6214e55b11d
Source dataset
uspto-grants-1992_06
Patent number
US05120738

Reaction notes

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