Acetic Acid → HCID 67794368, compound

HRID 892896Notes

Reaction equation

HRID 892896 reaction equation
CC1(C)[O:7][CH:6]([C:8]([NH:10][CH2:11][CH2:12][C:13]([O:15][C:16]2[CH:21]=[CH:20][C:19]([NH:22][C:23](=[O:41])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]/[CH:31]=[CH:32]\[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])=[CH:18][CH:17]=2)=[O:14])=[O:9])[C:5]([CH3:43])([CH3:42])[CH2:4][O:3]1.C(O)(=O)C>O>[OH:7][CH:6]([C:5]([CH3:42])([CH3:43])[CH2:4][OH:3])[C:8]([NH:10][CH2:11][CH2:12][C:13]([O:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23](=[O:41])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]/[CH:31]=[CH:32]\[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])=[CH:18][CH:17]=1)=[O:14])=[O:9]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 67795864HCID 67795864, compound

Product 1

HCID 67794368HCID 67794368, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A solution of 500 mg of 4-(Oleoylamino)phenyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate in a mixed solvent composed of 20 ml of acetic acid and 10 ml of water was stirred at room temperature for 15 hours. 20 ml of water was then added to the reaction mixture, which was then extracted with methylene chloride. The methylene chloride layer was washed with water, and dried over anhydrous sodium sulfate. After removal of the solvent under vacuum evaporation, the residue obtained was subjected to silica gel column chromatography to obtain 395 mg of the title compound (yield: 85%).

Workup

  1. extractionwas then extracted with methylene chloride
  2. washThe methylene chloride layer was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customAfter removal of the solvent
  5. customunder vacuum evaporation
  6. customthe residue obtained

Sources & evidence

ORD record
ord-6782daa3ce7046528cd7a93296fd3abe
Source dataset
uspto-grants-1992_06
Patent number
US05120738

Reaction notes

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