HCID 23174739, compound → HCID 20468917, compound

Participants

Reaction Steps

DL-hydroxyphenylglycine HCL (10.0 g) is reacted with (+)-phenylethanesulfate NH4 (9.98 g) in water (10 ml) to form two diastereomers of DL-hydroxyphenylglycine (+)-phenylethanesulfate. DL-hydroxyphenylglycine (0.82 g) is added to the reaction mixture and the mixture is heated in an autoclave at 140° C. for 12 hours. After completion of the reaction, 50% aqueous solution of (+)-phenylethanesulfate (1.8 g) and water (10 ml) are added to the reaction mixture and the mixture is stirred at room temperature for 1 hour. The crystals thus formed are filtered off and dried to give D-hydroxyphenylglycine (+)-phenylethanesulfate (17.73 g)·[a]D25 -76.5° (c=1, CH3OH), Optical purity 97.3%.

Provenance & Evidence