反应详情

Bromine is added dropwise to a solution of 2,6-dimethylanisole (12.0 g) in chloroform (100 ml) at about 5°. The solution is stirred at 5° for 2 hr and then allowed to warm to 20°-25°. The reaction mixture is poured into ice-water, and the phases are separated. The chloroform phase is washed with water, aqueous sodium bisulfite solution, then with water, dried over sodium sulfate and concentrated under reduced pressure to give 3,5-dimethyl-4-methoxybromobenzene.

1. temperatureto warm to 20°-25°
2. customthe phases are separated
3. washThe chloroform phase is washed with water, aqueous sodium bisulfite solution
4. dry with materialwith water, dried over sodium sulfate
5. concentrationconcentrated under reduced pressure