Fumaric Acid → HCID 86745910, compound

HRID 893013Notes

Reaction equation

HRID 893013 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[CH3:9][C:10]([C:13]1[CH:18]=[C:17]([CH2:19][N:20]2[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][N:31]([C:34]4[CH:39]=[C:38]([N:40]5[CH2:44][CH2:43][CH2:42][CH2:41]5)[N:37]=[C:36]([N:45]5[CH2:49][CH2:48][CH2:47][CH2:46]5)[N:35]=4)[CH2:30][CH2:29]3)[CH2:22][CH2:21]2)[CH:16]=[C:15]([C:50]([CH3:53])([CH3:52])[CH3:51])[C:14]=1[OH:54])([CH3:12])[CH3:11]>CO>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[CH3:53][C:50]([C:15]1[CH:16]=[C:17]([CH2:19][N:20]2[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][N:31]([C:34]4[CH:39]=[C:38]([N:40]5[CH2:44][CH2:43][CH2:42][CH2:41]5)[N:37]=[C:36]([N:45]5[CH2:46][CH2:47][CH2:48][CH2:49]5)[N:35]=4)[CH2:30][CH2:29]3)[CH2:22][CH2:21]2)[CH:18]=[C:13]([C:10]([CH3:12])([CH3:11])[CH3:9])[C:14]=1[OH:54])([CH3:51])[CH3:52]

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 19894522HCID 19894522, compound

Product 1

HCID 86745910HCID 86745910, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The fumarate salt is prepared by addition of fumaric acid (84 mg) to 2,6-bis(1,1-dimethylethyl)-4[[4-[2-[4-(2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl)-1-piperazinyl]ethyl]-1-piperazinyl]methyl]phenol (EXAMPLE 24) in methanol to obtain the title compound.

Sources & evidence

ORD record
ord-c771febba5df4a2e9d2622d4f4777ef3
Source dataset
uspto-grants-1992_06
Patent number
US05120843

Reaction notes

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