Diethyl Ether → HCID 86745911, compound

HRID 893014Notes

Reaction equation

HRID 893014 reaction equation
[CH2:1]([NH:3][C:4]1[C:5]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][O:22][C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=3)[CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1)[CH3:2].[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35].CCOCC>CO>[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35].[CH2:1]([NH:3][C:4]1[C:5]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][O:22][C:23]3[CH:24]=[CH:25][C:26]([O:29][CH3:30])=[CH:27][CH:28]=3)[CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1)[CH3:2]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 444972Fumaric AcidHCID 19894533HCID 19894533, compound

Product 1

HCID 86745911HCID 86745911, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-Ethyl-2-[4-[6-(4-methoxyphenoxy)hexyl]-1-piperazinyl]-3-pyridinamine (EXAMPLE 26) is dissolved in methanol (10 ml), fumeric acid (0.24 g) is added and the mixture allowed to stand for 30 min at 20°-25°. The mixture is clouded with ether and allowed to crystallize at about 15° to give the title compound.

Workup

  1. customto crystallize at about 15°

Sources & evidence

ORD record
ord-f41be6b244f643528665df5d93844ec6
Source dataset
uspto-grants-1992_06
Patent number
US05120843

Reaction notes

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