Sodium Azide → HCID 14842618, compound

Participants

Reaction Steps

The chloro ester 4a (5.5 g, 19.8 mmol) and NaN3 (5.5 g, 84.6 mmol) were dissolved 200 ml of DMF in a 75° C. oil bath and stirred at this temp. for 64 h, then worked up using method B. This gave 4.5 g (80% crude yield)of an oil, which was used directly in the next step. 1H NMR (CDCl3) δ1.28 (t, 3H), 1.41/1.46 (2s, 9H), 2.17 (m, 1H), 2.32 (m, 1H), 3.52 (m, 1H), 3.70 (dd, 1H), 4.18 (m, 3H), 4.34 (m, 1H). FAB MS; MH+ calc. for C12H21N4O4 =235.1563, found 285.1574.

Provenance & Evidence