HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4R)-1-(tert-Butoxycarbonyl)-4-cyano-D-proline → HCID 14842647, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4R)-1-(tert-Butoxycarbonyl)-4-cyano-D-proline | HCID 14842643 | — |
| Reactant | (4S)-4-(Aminomethyl)-1-(tert-butoxycarbonyl)-L-proline | HCID 14842646 | — |
| Product | HCID 14842647 | HCID 14842647 | 95% |
Reaction Steps
Cyano acid 28 (650 mg, 2.7 mmol) was hydrogenated as for the synthesis of 12, and the produce was crystallized from water/ethanol/ether to give 630 mg (95% yield), m.p.=187°-189° C. (decomposition). 1H NMR (D2O) δ 1.40/1.44 (2s, 9H), 1.62 (m, 1H). 2.55 (m, 2H), 3.13 (m, 2H), 3.75 (m, 2H), 4.10 (m, 1H). Anal. (C11H20N2O4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05120859 |
| Source dataset | uspto-grants-1992_06 |
| ORD ID | ord-c8e4ff29e4684e9db5bd0d1d50531529 |
| Source note | uspto-grants-1992_06 |