(4S)-4-(Aminomethyl)-1-(tert-butoxycarbonyl)-L-proline → 1-(1,1-Dimethylethyl) (2S,4R)-4-(aminomethyl)-1,2-pyrrolidinedicarboxylate

Participants

Reaction Steps

Cyano acid benzyl acid ester 36 (3.0 g, 9.1 mmol) was hydrogenated as for the synthesis of 12, and the product was crystallized from water/ethanol/ether to give 1.5 g (67% yield), m.p.=230°-231° C. 1H NMR (D2O) δ1.41/1.46 (2s, 9H), 2.11 (m, 1H), 2.60 (m, 1H), 3.12 (m, 2H), 3.73 (m, 1H), 4.17 (dd, J=9.0/3.9,1H).

Provenance & Evidence