Water → HCID 53756100, compound

Participants

Reaction Steps

4 g of 2-(1,2,4-triazol-1-ylmethyl)-2-(4-chlorophenyl)-3-(2-trifluoromethylphenyl)oxirane are dissolved in 80 ml of methanol and, after addition of 1.2 g of sodium methylate, refluxed for one hour. The solution is then cooled to room temperature (20° C.), 50 ml of water are added and the mixture is extracted by shaking several times with methyl tert-butyl ether. The isolated organic phase is washed twice with water, dried over sodium sulfate and concentrated, resulting in 3.8 g (95 %) of 1-(1,2,4-triazol-1-yl)-2-(4-chlorophenyl)-3-(2-trifluoromethylphenyl)-1-propen-3-ol, melting point 161° C.

Provenance & Evidence