Pyridine → N-(6-methoxypyridin-3-yl)cyclopropanecarboxamide

Participants

Reaction Steps

A solution of 5-amino-2-methoxy pyridine (12.4 g, 0.10 mol) and pyridine (10 ml) in dichloromethane (200 ml) was stirred at room temperature. Cyclopropane carboxylic acid chloride (9.1 ml, 0.10 mol) was added dropwise to the reaction mixture at such a rate to maintain the temperature at 20°-30° C. After complete addition the reaction mixture was stirred at room temperature for a further one hour, then washed with 5% sodium hydroxide (200 ml), water (100 ml) and dried over anhydrous magnesium sulphate. Removal of the solvent gave N-(2-methoxy-5-pyridyl)-cyclopropane carboxamide (16.7 g, 87%) m.p. 130-131° C.

Provenance & Evidence