Phosphorus pentachloride → HCID 19892769, compound

Participants

Reaction Steps

N-(2-fluoro-5-pyridyl)-cyclopropane carboxamide (2.0 g, 0.011 mol) was added portionwise to a stirred solution of phosphorus pentachloride (2.31 g, 0.011 mol) in dichloromethane (20 ml) under a nitrogen atmosphere at room temperature. After complete addition the mixture was stirred at room temperature for one hour and then heated at reflux for a further one hour. The reaction mixture was then evaporated under vacuum to gave N-(2-fluoro-5-pyridyl)-cyclopropylmethanimidoyl chloride (2.1 g, 96%) which was used in Stage 3 without further purification or characterisation.

Provenance & Evidence