Dimethylformamide dimethyl acetal → HCID 15029614, compound

Participants

Reaction Steps

A solution of 3-(2-methoxy-5, 6, 7, 8-tetrahydronaphth-1-yl)-N-formylserine (2930 mg, 10 mmol) and N,N-dimethylformamide dimethyl acetal (7100 mg, 60 mmol) in dry chloroform (50 ml) is heated at reflux temperature for 2 hrs. The reaction mixture is evaporated under vacuum, the residue dissolved in chloroform and filtered through a silica gel column. The eluateis evaporated under vacuum to give almost pure title compound in 85% yield (1970 mg).

Provenance & Evidence