Acetic Anhydride → HCID 15029615, compound

Participants

Reaction Steps

To a cooled solution of (E)-N-[2-(2-hydroxynaphth-1-yl) ethenyl] formamide (2133 mg, 10 mmol) in dry pyridine (5 ml) is added acetic anhydride (2042 mg, 20 mmol) and the mixture maintained at 0°-5° overnight. Thereupon the mixture is concentrated under vacuum, the residue dissolved in dichloromethane, the organic layer washed with water and then evaporated under reduced pressure. The crude product is crystallized from chloroform/methanol to yield pure title compound in 90% yield (2300 mg).

Provenance & Evidence