HCID 15029618, compound → HCID 15029619, compound

HRID 893088Notes

Reaction equation

HRID 893088 reaction equation
I([O-])(=O)(=O)=[O:2].[Na+].[C:7]1([S:13][CH:14]([C:19]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:22]=[CH:21][C:20]=2[O:29][CH3:30])[CH2:15][NH:16][CH:17]=[O:18])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>O.CO>[C:7]1([S:13]([CH:14]([C:19]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:22]=[CH:21][C:20]=2[O:29][CH3:30])[CH2:15][NH:16][CH:17]=[O:18])=[O:2])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 2

HCID 15029618HCID 15029618, compoundHCID 23667635Sodium periodate

Product 1

HCID 15029619HCID 15029619, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A concentrated solution of sodium metaperiodate (2139 mg. 10 mmol) in water is added dropwise at 0° C. under cooling to a solution of 1-(1-phenylthio-2-formylaminoethyl)-2-methoxy-naphthalene (3374 mg, 10 mmol) in methanol (100 ml). The reaction is then stirred at room temperature for 24 h. The solids are filtered off and washed several times with ethyl acetate (1000 ml). The filtrate and washings are combined and then evaporated under vacuum to yield crude title compound in about 100% yield (3534 mg ) which is used in the next step without further purification.

Workup

  1. filtrationThe solids are filtered off
  2. washwashed several times with ethyl acetate (1000 ml)
  3. customevaporated under vacuum

Sources & evidence

ORD record
ord-5584db22609e4a689aaa63fcce4e351b
Source dataset
uspto-grants-1992_06
Patent number
US05122537

Reaction notes

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