Hydrazine hydrate (1:1) → 4-Amino-2-methyl-2,3-dihydropyridazin-3-one

Participants

Reaction Steps

At 80° C., 240.8 g (1.38 mol) of 5-chloro-4-methoxy-1-methyl-6-pyridazone was added in portions to 1930 ml of hydrazine hydrate in such a manner that the temperature remained at 80° C. without further heating. After cooling, the precipitate was filtered off, washed and dried. There was obtained 112.8 g (65.3%) of 5-amino-1-methyl-6-pyridazone of melting point 191°-192° C.

Provenance & Evidence