3(2H)-Pyridazinone, 4,5-dichloro-2-methyl- → 4-Chloro-5-methoxy-2-methyl-2,3-dihydropyridazin-3-one

Participants

Reaction Conditions

Reaction Steps

295 g of 30% strength sodium methylate solution was added to 293 g (1.64 mol) of 4,5-dichloro-1-methyl-6-pyridazone in 690 ml of methanol in such a manner that a temperature of 30° C. was not exceeded. After cooling and stirring for 12 hours at 25° C., the precipitate which had formed was filtered off, washed and dried. There was obtained 241 g (84.3%) of 5-chloro-4-methoxy-1-methyl-6-pyridazone of melting point 189°-191° C.

Provenance & Evidence