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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 893220Generated: October 30, 2026

Thionyl Chloride → Ethyl 2-(chlorocarbonyl)-2-methoxypropionate

https://huagongshe.com/reaction/893220

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
ReactantHCID 86745933HCID 86745933—
ProductEthyl 2-(chlorocarbonyl)-2-methoxypropionateHCID 19096847100%

Reaction Steps

Mon-ethyl methoxy(methyl)malonate (14.52 grams, 0.08 mole) was reacted with thionyl chloride (19.61 grams, 0.16 mole) at 50° C. for a 13-hour reaction period with an additional holding period of approximately 32 hours at room temperature. Vacuum evaporation of the excess thionyl chloride gave 15.2 grams (0.08 mole) of ethyl 2-(chlorocarbonyl)-2-methoxypropionate. NMR analysis of the product indicated the following:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05123951
Source datasetuspto-grants-1992_06
ORD IDord-e9cff9277721458b8b5cff4952132e3b
Source noteuspto-grants-1992_06