3-Chloroaniline → HCID 19096892, compound

HRID 893236Notes

Reaction equation

HRID 893236 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[CH3:9][O:10][CH:11]([C:17]([O-])=[O:18])[C:12]([O:14][CH2:15][CH3:16])=[O:13].C1(N=C=NC2CCCCC2)CCCCC1>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][C:17](=[O:18])[CH:11]([O:10][CH3:9])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 79323-ChloroanilineHCID 10868DicyclohexylcarbodiimideHCID 85543209HCID 85543209, compound

Product 1

HCID 19096892HCID 19096892, compoundYield 30%

Procedure

3-Chloroaniline (2.82 grams, 0.02 mole), mono-ethyl methoxymalonate (3.58 grams, 0.02 mole), prepared in Example LIII Part B, and 1,3-dicyclohexylcarbodiimide (4.50 grams, 0.02 mole) were reacted in a manner similar to that described in Example LVII to give 1.60 grams (0.006 mole) of ethyl 3-[(3-chlorophenyl)amino]-2-methoxy-3-oxopropanoate having melting point of 43.50° C.-46.50° C.

Workup

  1. customwere reacted in a manner similar to

Sources & evidence

ORD record
ord-ac6a828194d041cabd3e6ad8a961eb96
Source dataset
uspto-grants-1992_06
Patent number
US05123951

Reaction notes

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