Sodium Cyanide → HCID 15702884, compound

HRID 893268Notes

Reaction equation

HRID 893268 reaction equation
[C-:1]#[N:2].[Na+].Cl[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][CH2:14][Cl:15])=[CH:8][CH:7]=1>C(O)C>[Cl:15][CH2:14][CH2:13][CH2:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][C:1]#[N:2])=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 155255Benzene, 1-(chloromethyl)-4-(3-chloropropyl)-

Product 1

HCID 15702884HCID 15702884, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a 100 ml of round bottomed two-necked flask 4.4 g of NaCN, 18.2 g of 1-(4-chloromethylphenyl)3-chloropropane and 44.8 ml of 90% ethanol are added and boiled at reflux for 5 hours. The feedstock is cooled to room temperature and the precipitate is filtered by suction. The filtrate is concentrated by evaporation. The residue is absorbed in 700 ml of diethyl ether, washed to neutrality with 2×250 ml of distilled water and dried with sodium sulfate. The solution is evaporated to dryness in a rotary evaporator.

Workup

  1. temperatureat reflux for 5 hours
  2. filtrationthe precipitate is filtered by suction
  3. concentrationThe filtrate is concentrated by evaporation
  4. customThe residue is absorbed in 700 ml of diethyl ether
  5. washwashed
  6. dry with materialdried with sodium sulfate
  7. customThe solution is evaporated to dryness in a rotary evaporator

Sources & evidence

ORD record
ord-eeb13ca551e64092a22861cab10acadb
Source dataset
uspto-grants-1992_06
Patent number
US05124326

Reaction notes

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